Rhabdomyosarcoma in children

What is rhabdomyosarcoma in children?

Rhabdomyosarcoma typically begins in the muscle cells, and the most common sites are the head, neck, bladder, vagina, arms, legs and trunk. Rhabdomyosarcoma can also be found in places where there is very little or no skeletal muscles, such as the prostate, middle ear and bile duct system.

Rhabdomyosarcoma may spread to other parts of the body, such as the lymph nodes, lungs, bone or bone marrow.

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Each year in the U.S., between 400 and 500 children are diagnosed with rhabdomyosarcoma. Children are usually diagnosed between birth and age 15.

What are the different types of rhabdomyosarcoma in children?

There are two types of rhabdomyosarcoma. The type depends on a genetic change that occurs in some types of rhabdomyosarcoma.

1. Fusion-positive rhabdomyosarcoma is commonly found in soft tissue of the head, neck area, torso and arms and legs. This is the rarest type of rhabdomyosarcoma and occurs more commonly in adolescents.

2. Fusion-negative rhabdomyosarcoma typically shows up in the head and neck and genitourinary area. This type of rhabdomyosarcoma happens most commonly in younger children.

What are the signs and symptoms of rhabdomyosarcoma in children?

Because rhabdomyosarcoma can occur anywhere in the body, symptoms may vary based on the size and location of the tumor. Common symptoms include a mass that may or may not be painful. This mass can cause tingling, numbness, pain or restricted movement.

Other common symptoms of rhabdomyosarcoma in children include:

• Bleeding from the nose, vagina or rectum

• Trouble with urination or bowel movements

• Drooping eyelid or protruding eye

How is rhabdomyosarcoma in children diagnosed?

Diagnosis usually starts when your pediatrician notices an unusual lump or swelling in your child’s body. Next, a radiologist will do an ultrasound or MRI (magnetic resonance imaging) that reveals a tumor. Then, when you make an appointment with us, we’ll do a biopsy (a procedure where your child’s doctor removes a few cells from the tumor to be examined by a laboratory).

We identify the type of cancer by looking at the tumor cells under the microscope and studying its DNA. We also get detailed images of the tumor, through tests like an MRI, CT and PET-CT scans. These images show us how big the tumor is and whether it has spread to other places in the body.

Usamos el tipo, el tamaño y la ubicación del tumor para decidir qué tratamiento funcionará mejor para su hijo.

What causes rhabdomyosarcoma in children?

In most cases, there is no known cause, but some people may have an increased risk of developing rhabdomyosarcoma due to genetics. We know that patients with Li-Fraumeni syndrome, neurofibromatosis, or RASopathies (abnormalities in the RAS gene) are at increased risk of developing rhabdomyosarcoma.

How is rhabdomyosarcoma in children treated?

Treatment typically includes a combination of chemotherapy to destroy the cancer cells, surgery to remove the tumor and/or radiation to kill the tumor cells. Your child's therapy will depend on their age, tumor location, tumor type and extent of the cancer.

Our pediatric oncologists work closely with the surgery and radiation oncology teams to provide seamless care. Our surgeons are experts in the complex surgeries used to treat rhabdomyosarcoma. Our radiation oncologists use cutting-edge techniques to effectively kill the tumor cells while also minimizing toxicity.

En Children's Health, siempre buscamos tratamientos nuevos y mejores. Nuestros pacientes tienen acceso a ensayos clínicos que solo podrían estar disponibles en unos pocos hospitales. Proporcionamos acceso a las opciones de tratamiento más recientes para pacientes con cánceres recidivantes a través de ensayos clínicos que se ofrecen en nuestro Programa de terapéutica experimental. También usamos pruebas genéticas, a través de nuestro Programa de medicina de precisión, para identificar mutaciones genéticas que pueden tratarse con medicamentos, que proporcionan un tratamiento más eficaz con menos efectos secundarios.