transforming pediatric health care

Gastroenterology

Technically variant grafts significantly close the gap in pediatric liver transplant access

Pediatric split liver transplant surgery is rare, with only 10 U.S. centers offering it. Children’s Health began using technically variant grafts in 2024 and has since doubled the national average, expanding access and reducing waitlist mortality.

Cardiology, +1 more

Groundbreaking pediatric cardio-oncology program transforming care

The Pediatric Cardio-Oncology Program at Children’s Health is one of the first in the nation offering a dedicated clinic focused on protecting the heart health of children battling cancer or in remission.

Gastroenterology

First evidence-based guidelines for pediatric IBS and functional abdominal pain

Learn how Children’s Health collaborated on the first-ever global guidelines for pediatric IBS and functional abdominal pain, offering gastroenterologists evidence-based recommendations to improve care for gut-brain interaction disorders.

Neonatology

Study reveals CBT reduces perceived child vulnerability after prolonged NICU stays

Standard NICU care prioritizes the infant, but parents’ perceptions of vulnerability can affect development. A new Children’s Health study shows cognitive behavioral therapy can reduce parental perceived child vulnerability after NICU discharge.

Nephrology

Case study: siRNA therapy enables kidney-only transplant in child with rare PH1

Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder that causes excess oxalate, leading to kidney failure and systemic damage. While liver transplant is the only cure, FDA-approved therapies are making kidney-only transplants a viable option.

Neurology

First-in-kind study validates safety of thalamic sampling during SEEG in Children with DRE

New study at Children’s Health confirms the safety of sampling thalamic nuclei during SEEG in pediatric patients with drug-resistant epilepsy (DRE). The findings revealed that accurate thalamic mapping can improve neuromodulation targeting.

Behavioral Health

The Behavioral Health Vehicles Program at Children’s Health provides emergency transport services to children with mental health needs.

The Behavioral Health Vehicles Program at Children’s Health provides emergency transport services to children with mental health needs.

Pulmonology

This episode focuses on obstructive sleep apnea in children with cystic fibrosis and the critical need for proactive screening.

This episode focuses on obstructive sleep apnea in children with cystic fibrosis and the critical need for proactive screening.

Establishing the first-ever national standard of care for familial chylomicronemia syndrome (FCS)

Children’s Health helped develop a first-of-its-kind tool for diagnosing familial chylomicronemia syndrome (FCS) and contributed to an expert consensus on treatment approaches. Discover how this is improving pediatric FCS care.

4 innovations advancing multidisciplinary care for pediatric cerebrovascular disorders

Pediatric stroke, aneurysm, AVM and moyamoya disease require fast, coordinated care across subspecialties. See how Children's Health is transforming outcomes through on-site intervention capability, integrated decision-making and long-term follow-up.

Inside the only fetus-to-five neonatal brain program designed for high-risk infants

Learn how Children’s Health built the nation’s only “fetus-to-five” neonatal brain program – integrating prenatal, neuroNICU and follow-up care to improve outcomes for high-risk infants.

Promising phase 1 data advances novel immunotherapy trial for pediatric rhabdomyosarcoma

Children’s Health research showed that a combination chemotherapy-immunotherapy treatment is safe in children with solid tumors. A new trial is assessing the treatment’s efficacy in patients with relapsed and refractory rhabdomyosarcoma.

New evidence supports observation as first-line management for pediatric NTM lymphadenitis

Children’s Health research shows observation is a safe initial approach for pediatric cervicofacial NTM lymphadenitis. A retrospective study found most cases resolve without intervention.

Gastroenterology

Uncovering the esophageal microbiome and its role in pediatric esophageal disease

Research led by Children’s Health reveals the esophageal microbiome as an active immunologic environment, with disease-specific microbial patterns that may inform biomarker development, earlier diagnosis and targeted therapies.

Hematology & Oncology

Fertility preservation in pediatric oncology: A multidisciplinary approach to care and survivorship

Pediatric fertility preservation now includes advanced options giving hope to even the youngest patients. Our experts share their insights, based on years of experience at the leading edge of this rapidly evolving field.

Pulmonology

Bronchopulmonary dysplasia outcomes after tracheostomy: Data-driven paths to ventilator liberation

A study from Children’s Health provides insight on the timeline from tracheostomy to respiratory independence for children with bronchopulmonary dysplasia – and several keys to supporting their health and growth along the way.

Clinical Trial

A Randomized Controlled Trial of Abdominal Ultrasound (FAST) in Children with Blunt Torso Trauma

This study is a multi-center RCT to determine whether use of the FAST examination impacts care in hemodynamically stable children with blunt torso trauma.

Neurology

Focal Cerebral Arteriopathy Steroid (FOCAS) Trial

This trial in children with suspected focal cerebral arteriopathy (FCA) presenting with arterial ischemic stroke (AIS) or transient ischemic attack (TIA) comparing early corticosteroid treatment versus delayed/no corticosteroid treatment.

Nephrology

A Phase 3 Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Chronocort in the Treatment of Participants Aged 16 Years and Over with Congenital Adrenal Hyperplasia.

A Phase 3 Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Chronocort in the Treatment of Participants Aged 16 Years and Over with Congenital Adrenal Hyperplasia.

Neurology

Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea

The study is being conducted in order to evaluate objective change in cognition and expressive language after implant and therapy with the Inspire UAS System.

Hematology & Oncology

NCT04690322

Each patient will be randomly assigned to receive either extended half-life factor VIII based replacement therapy or non-FVIII based replacement therapy, which are both standard of care treatment for persons with Hemophilia A.

Cardiology

Protocol Title: A Phase 2/3 Randomized, Placebo-Controlled, Double-blind, Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants with Heart Failure

This study aims to compare the efficacy of vericiguat versus placebo on change in n-terminal pro-brain natriuretic peptide (NTproBNP) from baseline to Week 16 of the Base Period.

Pulmonology

NCT05268094

This is a prospective multicenter randomized interventional trial. Participants will be randomized to receive either an SPS or DAS.

Cardiology

NCT06080074

The overall study design is a prospective clinical trial that combines two individual study designs into one common protocol.