Quantification of Glucose-6-Phosphate (G6P) and Gamma-Aminobutyric Acid (GABA) in the brain using 7T MRI or 3T Spectroscopy in Lafora Disease and Neurogenetic Diseases.

after informed consent is obtained, the following information will be collected from their medical records. -General medical history -Lafora disease-specific medical history including stage/CGi score -Concomitant medications and procedures -Demographics -Weight and Height -Physical and neurological examinations -Blood and CSF data -electroencephalography eeG data MR Spectroscopy The brain G6P and GaBa will be measured by using non-invasive MRS at 7T or 3 Tesla at the advanced imaging Research Center, uTSouthwestern Medical Center. MRS scanning will be conducted on a Philips 'achieva' 7T scanner and/ or 3 Tesla , and spectral data acquired by positioning the subject head-first and supine in the MRi scanner (achieva, Philips Healthcare, Cleveland, oH), with the back of the head positioned in the center of a half-cylinder-shaped partial volume RF coil (Philips Healthcare, Cleveland, oH). MRS metabolite quantification will be achieved using standardized methods and protocols for MR spectroscopy (Ren, 20[See protocol for complete text]