Philip Warren Shaul, MD
Neonatologist
Professor at UT Southwestern Medical Center
- Languages Spoken:
- English
Biography
For the thousands of children diagnosed with respiratory conditions each year, or those born at low birth weight or with birth defects and lung problems, the first few days and weeks can be precarious. Dr. Philip Shaul,Director, Center for Pulmonary and Vascular Biology, and the other specialists at Children’s Health℠ deliver the emergency interventions and multispecialty care that has made a difference to these children and families across the nation.
Dr. Shaul’s early interest in science and caring for children translated into a lifelong career.
“As a teenager trying to make money, I had an assortment of jobs that involved caring for children. At the same time, I was interested in science, so going to school for medicine was a good fit,” he says.
During a rotation in neonatology during medical school, Dr. Shaul further focused his career aspirations.
I am really glad we have many individuals in diverse disciplines with deep expertise here at Children’s that I can call on whenever needed.
“What struck me about neonatology was how rapidly medical issues in newborns can change and how rapidly they respond to therapies. It still amazes me that you can see dramatic change one way or the other within only four to six hours. Few branches of pediatrics are like that,” he says.
Dr. Shaul is a father of two and was a preemie when he was born, so he brings extra life experience to the practice of neonatology.
While his work can be emotional from the perspective of seeing infants do well and seeing infants not respond well to care, Dr. Shaul is constantly encouraged by his colleagues’ depth and diversity of expertise in comprehensively caring for newborns with extremely complex conditions.
“I am really glad we have many individuals in diverse disciplines with deep expertise here at Children’s that I can call on whenever needed,” he says.
Dr. Shaul is certified by the America Board of Pediatrics in neonatal-perinatal medicine. He earned his medical degree from the University of Cincinnati College of Medicine and served as a pediatric resident at Children's Medical Center of Cincinnati/University of Cincinnati. He completed a fellowship in neonatal-perinatal medicine at Women and Infants Hospital of Rhode Island/Brown University.
He is a Fellow of the American Academy of Pediatrics and a member of the Association of American Physicians, the American Society for Clinical Investigation and the Dallas County Medical Society, among others. He holds the Associates First Capital Corporation Distinguished Chair in Pediatrics at UT Southwestern Medical Center, with research interests in cardiovascular and metabolic disease.
Outside of his practice, Dr. Shaul enjoys family time, exercising and music.
Education and Training
- Medical School
- University of Cincinnati College of Medicine (1981)
- Residency
- Boston Children's Hospital (1984), Pediatrics
- Fellowship
- Brown University Medical School - GME (1986), Neonatal-Perinatal Medicine
- Board Certification
- American Board of Pediatrics/Neonatal-Perinatal
Departments and Programs
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Research Interests
- Apolipoprotein E receptor 2 (LRP8)
- Caveolae, lipid rafts
- Fc receptors and cardiometabolic disorders
- Membrane-associated estrogen receptors
- Nitric oxide synthase
- Scavenger receptor class B, type I (HDL receptor)
- Vascular basis of type 2 diabetes
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Publications
Publications
- 27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth., Wu Q, Ishikawa T, Sirianni R, Tang H, McDonald JG, Yuhanna IS, Thompson B, Girard L, Mineo C, Brekken RA, Umetani M, Euhus DM, Xie Y, Shaul PW Cell Rep 2013 Nov 5 3 637-45
- LXRß/estrogen receptor-a signaling in lipid rafts preserves endothelial integrity., Ishikawa T, Yuhanna IS, Umetani J, Lee WR, Korach KS, Shaul PW, Umetani M J. Clin. Invest. 2013 Jul
- Scavenger receptor class B type I is a plasma membrane cholesterol sensor., Saddar S, Carriere V, Lee WR, Tanigaki K, Yuhanna IS, Parathath S, Morel E, Warrier M, Sawyer JK, Gerard RD, Temel RE, Brown JM, Connelly M, Mineo C, Shaul PW Circ. Res. 2013 Jan 112 1 140-51
- Point mutations in the ERa Gai binding domain segregate nonnuclear from nuclear receptor function., Wu Q, Chambliss K, Lee WR, Yuhanna IS, Mineo C, Shaul PW Mol. Endocrinol. 2013 Jan 27 1 2-11
- Coupling of Fc? receptor I to Fc? receptor IIb by SRC kinase mediates C-reactive protein impairment of endothelial function., Sundgren NC, Zhu W, Yuhanna IS, Chambliss KL, Ahmed M, Tanigaki K, Umetani M, Mineo C, Shaul PW Circ. Res. 2011 Oct 109 10 1132-40
Books
- Physiology of Nitric Oxide in the Developing Lung. In Polin RA, Fox WW, Abman SH, eds. Fetal and Neonatal Physiology. 4th ed. Kinsella JP, Shaul PW. (2011). Philadelphia: Elsevier Saunders; 807-820.
- Pulmonary Hypertension Syndromes. In Levin DL, Morriss FC, eds. Essentials of Pediatric Intensive Care. Vol 2. Zellers TM, Shaul PW. (1997). Churchill Livingstone; 188-195.
- Regulation of eNOS in Caveolae. In Jasmin J, Frank P, Lisanti MP, eds. Caveolins and Caveolae: Roles in Signaling and Disease Mechanisms. Mineo C, Shaul PW. (2012.). New York: Springer; 51-62.
- Caveolae and Estrogen Receptor Signaling. In Lisanti ML, Frank PG, eds. Advances in Molecular and Cell Biology Series. Vol 36. Shaul PW, Chambliss KL. (2005). Elsevier; 109-123.
- Regulation of Endothelial NO Synthase Activity by Estrogen Receptors in a Steroid Receptor Fast-Action Complex (SRFC) In Caveolae. In Watson CS, ed. The Identities of Membrane Steroid Receptors. Shaul PW, Chambliss KL, Mineo C. (2003). Norwell, MA: Kluwer Academic Publishers; 27-36.
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Professional Activities
- American Academy of Pediatrics, Fellow (1987)
- American Pediatric Society (2003)
- American Society for Clinical Investigation (1999)
- Association of American Physicians (2013)
- Dallas County Medical Society (1987)
- Perinatal Research Society (1992-2013)
- Society for Pediatric Research (1990)
- The American Physiological Society (1999)
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Awards and Honors
- Association of American Physicians (2013)
- Associates First Capitol Corporation Distinguished Chair in Pediatrics (2011)
- Hall of Honor, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine (2010)
- President, Society for Pediatric Research (2005-2006)
- Co-director, Crystal Charity Ball Center for Research in Pediatric Critical Care (1997)
- Lowe Foundation Professorship in Pediatric Critical Care Research (1997-2011)
- Established Investigator Award, AHA (1993)
