Optimizing Individual Nutrition in Preterm Very Low Birth Weight Infants

Prospective cohort 2015-2018: quality improvement (Qi) project and follow-up study visits: n [?]200 Primary study endpoints: Specific aim1: Growth insufficiency at 36 weeks PMa Small head circumference at 36 weeks PMa Change in length z score from birth to 36 weeks Specific aim 2: accelerated disproportionate growth: high weight for length at discharge and excessive fat 1-3 years Findings suggestive of metabolic syndrome at 1-3 years adjusted risk for disproportionate growth Specific aim 3 (sub-study): Difference between length measured by infantometer and length measured by the stadiometer inter-observer variability intra-observer variability - Serum levels of adipokines and kidney function abnormalities assessed by serum level of cystatin C at discharge or 36 weeks of PMa, whatever comes first; - Measurement of body composition by air displacement plethysmography at discharge or 36 weeks of PMa, whatever comes first; Duration of the study: 6.5 years (3.5-year cohort with 3 years of follow-up)