Luis Fernando Sifuentes-Dominguez, MD
Pediatric Gastroenterologist
Assistant Professor at UT Southwestern Medical Center
- Languages Spoken:
- English
Education and Training
- Medical School
- Universidad La Salle (2005)
- Residency
- Connecticut Childrens Medical Center (2012), Pediatrics
Hospital Infantil de Mexico Federico Gomez (2008), Pediatrics - Fellowship
- UT Southwestern - Children's Medical Center (2015), Pediatric Gastroenterology
- Board Certification
- American Board of Pediatrics/Gastroenterology
Conditions
- Abdominal migraines
- Achalasia
- Celiac disease
- Chronic abdominal pain (stomach ache)
- Colic
- Colon polyps
- Colorectal cancer (CRC)
- Constipation
- Cyclic vomiting syndrome (CVS)
- Diarrhea
- Dysphagia (swallowing disorder)
- Encopresis
- Esophageal stricture
- Failure to thrive (FTT)
- Familial adenomatous polyposis (FAP)
- Fecal incontinence
- Feeding disorder (PFD)
- Functional abdominal pain syndrome (FAPS)
- Gastroenteritis (stomache flu)
- Gastroesophageal reflux disease (GERD)
- Gastrointestinal (GI) bleeding
- Hirschsprung's disease
- Inflammatory bowel disease (IBD)
- Irritable bowel syndrome (IBS)
- Lactose intolerance
- Malabsorption
- Microscopic colitis (lymphocytic colitis or collagenous colitis)
- Nausea and vomiting
- Necrotizing enterocolitis (NEC)
- Pediatric H. pylori infection
- Peptic ulcer
- Rumination syndrome (merycism)
- Ulcerative colitis (UC)
Treatments
Departments and Programs
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Research Interests
- Identifying the genetic causes of early onset Inflammatory Bowel Disease
- Role of enteroendocrine cells in inflammatory bowel disease pathogenesis
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Publications
- Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection. Hu Z, Zhang C, Sifuentes-Dominguez L, Zarek CM, Propheter DC, Kuang Z, Wang Y, Pendse M, Ruhn KA, Hassell B, Behrendt CL, Zhang B, Raj P, Harris-Tryon TA, Reese TA, Hooper LV, Science 2021 11 374 6568 eabe6723
- Paneth cell-derived growth factors support tumorigenesis in the small intestine. Chen Q, Suzuki K, Sifuentes-Dominguez L, Miyata N, Song J, Lopez A, Starokadomskyy P, Gopal P, Dozmorov I, Tan S, Ge B, Burstein E, Life Sci Alliance 2021 Mar 4 3
- Structural and mechanistic insights into secretagogin-mediated exocytosis. Qin J, Liu Q, Liu Z, Pan YZ, Sifuentes-Dominguez L, Stepien KP, Wang Y, Tu Y, Tan S, Wang Y, Sun Q, Mo X, Rizo J, Burstein E, Jia D, Proc. Natl. Acad. Sci. U.S.A. 2020 Mar 117 12 6559-6570
- NK cell defects in X-linked pigmentary reticulate disorder. Starokadomskyy P, Wilton KM, Krzewski K, Lopez A, Sifuentes-Dominguez L, Overlee B, Chen Q, Ray A, Gil-Krzewska A, Peterson M, Kinch LN, Rohena L, Grunebaum E, Zinn AR, Grishin NV, Billadeau DD, Burstein E, JCI Insight 2019 Nov 4 21
- SCGN deficiency results in colitis susceptibility. Sifuentes-Dominguez LF, Li H, Llano E, Liu Z, Singla A, Patel AS, Kathania M, Khoury A, Norris N, Rios JJ, Starokadomskyy P, Park JY, Gopal P, Liu Q, Tan S, Chan L, Ross T, Harrison S, Venuprasad K, Baker LA, Jia D, Burstein E, Elife 2019 Oct 8
- Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer. Zhu W, Miyata N, Winter MG, Arenales A, Hughes ER, Spiga L, Kim J, Sifuentes-Dominguez L, Starokadomskyy P, Gopal P, Byndloss MX, Santos RL, Burstein E, Winter SE, J. Exp. Med. 2019 Jul
- Mosaic Tetrasomy 9p Associated With Inflammatory Bowel Disease. Sifuentes-Dominguez L, Starokadomskyy P, Welch J, Gurram B, Park JY, Koduru P, Burstein E, J Crohns Colitis 2019 Apr
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Professional Activities
- Crohn's and Colitis Foundation of America, North Texas Dallas Chapter Medical Advisory Committee (2016)
- Member, Crohn's and Colitis Foundation of America (2014)
- Member, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (2012)
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Awards and Honors
- Teaching Resident Award - University of Connecticut School of Medicine (2012)
- Excellence in Research Award - UTSW Department of Pediatrics Senior Fellows Research Day (2015)
- W.W. Caruth Scholar - Children's Medical Center Foundation (2015)
- Endoscopy Prize - NASPGHAN (2014)
