Benjamin Morris Greenberg, MD
Pediatric Neurologist
Professor at UT Southwestern Medical Center
- Languages Spoken:
- English
Biography
Benjamin M. Greenberg, M.D., M.H.S., is a professor and the Cain Denius Scholar in Mobility Disorders in the Department of Neurology and Neurotherapeutics and the Department of Pediatrics at UT Southwestern Medical Center.
He received a Master of Health Sciences degree from the Johns Hopkins School of Public Health. From there, he earned his medical degree at Baylor College of Medicine and went on to complete an internship in internal medicine at Rush-St. Luke's-Presbyterian Hospital in Chicago. He completed a residency in neurology and served as a chief resident at Johns Hopkins Hospital in Baltimore.
Prior to his recruitment to UT Southwestern in 2009, Dr. Greenberg was on the faculty of the Johns Hopkins Division of Neuroimmunology, serving as the director of the Encephalitis Center and co-director of the nation’s first dedicated Transverse Myelitis Center.
He serves as director of the Transverse Myelitis and Neuromyelitis Optica Program, the Pediatric Demyelinating Disease Program at Children’s Health℠ – which he established as one of only two U.S. programs of its kind – and the Neurosciences Clinical Research Center.
Dr. Greenberg is an internationally recognized expert in treating rare autoimmune disorders of the central nervous system. He is the principal investigator for the first large-scale study of pediatric TM coordinator centers throughout North America in a collaborative effort to better understand this rare disease.
Dr. Greenberg splits his clinical time between adult and pediatric patients, routinely consulting on the inpatient units of William P. Clements University Hospital, Parkland Memorial Hospital and Children’s Medical Center.
His research focuses on better diagnosing, prognosticating and treating demyelinating diseases and nervous system infections. He also coordinates clinical trials to evaluate new treatments to prevent neurologic damage and restore function to affected patients.
In addition, Dr. Greenberg has led an effort to improve biorepository development and create uniform protocols for sample handling and analysis. As part of this initiative, his collaborative research has identified novel biomarkers that may be key to distinguishing between patients with various neurologic disorders.
Certified by the American Board of Psychiatry and Neurology, Dr. Greenberg is a three-time Texas Monthly Rising Star.
Education and Training
- Medical School
- Baylor College of Medicine (2001)
- Internship
- Rush Presbyterian University Medical College (2002), Internal Medicine
- Residency
- John Hopkins Hospital (2005), Neurology
- Board Certification
- American Board of Psychiatry and Neurology
Conditions
- Multiple sclerosis (MS)
- Neuromyelitis optica spectrum disorder (NMOSD)
- Optic neuritis (ON)
- Paralysis
- Transverse myelitis (TM)
- Acute flaccid myelitis
Departments and Programs
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Research Interests
- Acute disseminated encephalomyelitis (ADEM)
- Acute flaccid myelitis
- anti-MOG antibody associated disease
- anti-NMDAR antibody encephalitis
- Autoimmune encephalitis
- Biomarkers of disease
- Clinical treatment trials
- Multiple sclerosis
- Neuromyelitis optica
- Optic neuritis
- Transverse myelitis
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Publications
Publications
- Astrocytic stress response is induced by exposure to astrocyte-binding antibodies expressed by plasmablasts from pediatric patients with acute transverse myelitis. Smith C, Telesford KM, Piccirillo SG, Licon-Munoz Y, Zhang W, Tse KM, Rivas JR, Joshi C, Shah DS, Wu AX, Trivedi R, Christley S, Qian Y, Cowell LG, Scheuermann RH, Stowe AM, Nguyen L, Greenberg BM, Monson NL Journal of Neuroinflammation 2024 Dec 21
- Correction: Evidence of brain target engagement in Parkinson’s disease and multiple sclerosis by the investigational nanomedicine, CNM- Au8, in the REPAIR phase 2 clinical trials (Journal of Nanobiotechnology, (2023), 21, 1, (478), 10.1186/s12951-023-02236-z) Ren J, Dewey RB, Rynders A, Evan J, Evan J, Ligozio S, Ho KS, Sguigna PV, Glanzman R, Hotchkin MT, Dewey RB, Greenberg BM Journal of Nanobiotechnology 2024 Dec 22
- Development and validation of a claims-based algorithm to identify patients with Neuromyelitis Optica Spectrum disorder. Patel AM, Exuzides A, Yermilov I, Dalglish H, Gibbs SN, Reddy SR, Chang E, Paydar C, Broder MS, Cohan S, Greenberg B, Levy M Journal of the Neurological Sciences 2024 Aug 463
- Immune-mediated myositis following gene therapy for Duchenne muscular dystrophy: a case report. Iannaccone ST, Cai C, Rhem B, Batley K, Rajaram V, Greenberg BM, Dharia S, Zaidman CM Journal of neurology 2024 Aug 271 5659-5664
- AAV gene therapy for hereditary spastic paraplegia type 50: a phase 1 trial in a single patient. Dowling JJ, Pirovolakis T, Devakandan K, Stosic A, Pidsadny M, Nigro E, Sahin M, Ebrahimi-Fakhari D, Messahel S, Varadarajan G, Greenberg BM, Chen X, Minassian BA, Cohn R, Bonnemann CG, Gray SJ Nature medicine 2024 Jul 30 1882-1887
- Emerging Cerebrospinal Fluid Biomarkers of Disease Activity and Progression in Multiple Sclerosis. Cross AH, Gelfand JM, Thebault S, Bennett JL, Von Büdingen HC, Cameron B, Carruthers R, Edwards K, Fallis R, Gerstein R, Giacomini PS, Greenberg B, Hafler DA, Ionete C, Kaunzner UW, Kodama L, Lock C, Longbrake EE, Musch B, Pardo G, Piehl F, Weber MS, Yuen S, Ziemssen T, Bose G, Freedman MS, Anania VG, Ramesh A, Winger RC, Jia X, Herman A, Harp C, Bar-Or A JAMA neurology 2024 Apr 81 373-383
- Clinical analysis of myelin oligodendrocyte glycoprotein antibody-associated disease in a diverse cohort of children: A single-center observational study. Nguyen L, Wang CX, Hernandez RS, Greenberg BM Multiple Sclerosis and Related Disorders 2024 Apr 84
- Gene–environment interactions: Epstein–Barr virus infection and risk of pediatric-onset multiple sclerosis .Ziaei A, Solomon O, Casper TC, Waltz M, Weinstock-Guttman B, Aaen G, Wheeler Y, Graves J, Benson L, Gorman M, Rensel M, Mar S, Lotze T, Greenberg B, Chitnis T, Waldman AT, Krupp L, James JA, Hart J, Barcellos LF, Waubant E Multiple Sclerosis Journal 2024 Mar 30 308-315
- Bruton's Tyrosine Kinase Inhibitors for Multiple Sclerosis Treatment: A New Frontier. Greenberg BM Neurologic Clinics 2024 Feb 42 155-163
- Increased Intracranial Pressure in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. Nguyen L, Miles DK, Harder L, Singh S, Whittemore BA, Greenberg BM, Wang CX Neurology(R) neuroimmunology & neuroinflammation 2024 Jan 11
- Smouldering-Associated Worsening in Multiple Sclerosis: An International Consensus Statement on Definition, Biology, Clinical Implications, and Future Directions. Scalfari A, Traboulsee A, Oh J, Airas L, Bittner S, Calabrese M, Garcia Dominguez JM, Granziera C, Greenberg B, Hellwig K, Illes Z, Lycke J, Popescu V, Bagnato F, Giovannoni G Annals of Neurology 2024
- Evidence of brain target engagement in Parkinson’s disease and multiple sclerosis by the investigational nanomedicine, CNM-Au8, in the REPAIR phase 2 clinical trials. Ren J, Rynders A, Evan J, Evan J, Ligozio S, Ho KS, Sguigna PV, Glanzman R, Hotchkin MT, Dewey RB, Greenberg BM Journal of Nanobiotechnology 2023 Dec 21
- VH2+ Antigen-Experienced B Cells in the Cerebrospinal Fluid Are Expanded and Enriched in Pediatric Anti-NMDA Receptor Encephalitis. Monson N, Smith C, Greenberg H, Plumb P, Guzman A, Tse K, Chen D, Zhang W, Morgan M, Speed H, Powell C, Batra S, Cowell L, Christley S, Vernino S, Blackburn K, Greenberg B Journal of Immunology 2023 Nov 211 1332-1339
- A place for biosimilars in the changing multiple sclerosis treatment landscape. Greenberg B, Giovannoni G Multiple Sclerosis and Related Disorders 2023 Sep 77
- Subclinical optic neuritis in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease. Nguyen L, Wang CX, Conger DL, Sguigna PV, Singh S, Greenberg BM Multiple Sclerosis and Related Disorders 2023 Aug 76
- Gene-environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures. Nasr Z, Schoeps VA, Ziaei A, Virupakshaiah A, Adams C, Casper TC, Waltz M, Rose J, Rodriguez M, Tillema JM, Chitnis T, Graves JS, Benson L, Rensel M, Krupp L, Waldman AT, Weinstock-Guttman B, Lotze T, Greenberg B, Aaen G, Mar S, Schreiner T, Hart J, Simpson-Yap S, Mesaros C, Barcellos LF, Waubant E Journal of Neurology, Neurosurgery and psychiatry 2023 Jul 94 518-525
- Rare and low-frequency coding genetic variants contribute to pediatric-onset multiple sclerosis. Horton MK, Shim JE, Wallace A, Graves JS, Aaen G, Greenberg B, Mar S, Wheeler Y, Weinstock-Guttman B, Waldman A, Schreiner T, Rodriguez M, Tillema JM, Chitnis T, Krupp L, Casper TC, Rensel M, Hart J, Quach HL, Quach DL, Schaefer C, Waubant E, Barcellos LF Multiple Sclerosis Journal 2023 Apr 29 505-511
- MOG and AQP4 Antibodies among Children with Multiple Sclerosis and Controls. Author Collaboration US, Gaudioso CM, Mar S, Casper TC, Codden R, Nguyen A, Aaen G, Benson L, Chitnis T, Francisco C, Gorman MP, Goyal MS, Graves J, Greenberg BM, Hart J, Krupp L, Lotze T, Narula S, Pittock SJ, Rensel M, Rodriguez M, Rose J, Schreiner T, Tillema JM, Waldman A, Weinstock-Guttman B, Wheeler Y, Waubant E, Flanagan EP Annals of Neurology 2023 Feb 93 271-284
- ATP line splitting in association with reduced intracellular magnesium and pH: a brain 31P MR spectroscopic imaging (MRSI) study of pediatric patients with myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGADs). Ren J, Yu F, Greenberg BM NMR in biomedicine 2023 Feb 36
- Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity. Shinoda K, Li R, Rezk A, Mexhitaj I, Patterson KR, Kakara M, Zuroff L, Bennett JL, von Büdingen HC, Carruthers R, Edwards KR, Fallis R, Giacomini PS, Greenberg BM, Hafler DA, Ionete C, Kaunzner UW, Lock CB, Longbrake EE, Pardo G, Piehl F, Weber MS, Ziemssen T, Jacobs D, Gelfand JM, Cross AH, Cameron B, Musch B, Winger RC, Jia X, Harp CT, Herman A, Bar-Ora A Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 120
- Disease associations of excessive daytime sleepiness in multiple sclerosis: A prospective study. Sguigna PV, Toranian S, Tardo LM, Blackburn KM, Horton LA, Conger D, Meltzer E, Hogan RN, McCreary M, Zee PC, Takahashi JS, Greenberg BM Multiple Sclerosis Journal - Experimental, Translational and Clinical 2023 Jan 9
- Evolving Considerations in the Treatment and Management of Multiple Sclerosis: Implementing Expert Switching and Sequencing Strategies. Greenberg B Journal of Managed Care Medicine 2023 26 36-40
Books
- Myelopathy: A Guide to Diagnosis and Treatment, Benjamin Greenberg (Ed.) (2022).
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Professional Activities
- American Academy of Neurology (2002)
- American Neurological Association (2014)
- International Society for Biological and Environmental Repositories (2009)
- Siegel Rare Neuroimmune Association (2004)
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Awards and Honors
- D Magazine Best Doctors in Dallas (2016-2023)
- UT Southwestern Medical School Teaching Award (2017-2022)
- University of Texas Southwestern Academy of Teachers (2016)
- UT Southwestern Medical School Teaching Award (2016)
- University of Texas Board of Regents Teaching Award (2015)
- UT Southwestern Medical School Teaching Award (2009-2015)
- Fred Baskin Investigator Award Research Award (2011)
- UT Southwestern Neurology Trephined Cranium Teaching Award (2010)
- Accelerated Cure Project Physician of Distinction Award (2009)
- Frank Ford - Depart of Neurology Teaching Award (2008)
- Guy McKhann - Resident Teaching Award (2005)
- Service Award From Maryland - Multiple Sclerosis Society (2004)
- Intern of the Year Award - Rush Internal Medicine (2002)
- Alpha Omega Alpha Honor Society, Baylor College of Medicine (2001)
