APEC1621: NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice)

The Pediatric MaTCH (Molecular analysis for Therapy Choice) study, will match targeted agents with specific molecular changes identified using genomic sequencing technologies in refractory/recurrent tumors from children and adolescents with cancer. Pediatric MaTCH will employ an analytically validated next-generation sequencing targeted assay of more than 4,000 different mutations (SnVs, indels, copy number alterations, and gene fusions) across more than 140 genes. This assay will be coupled to a computer algorithm that uses pre-existing definitions and prioritization of target-agent pairs to assign patients by actionable mutation results to a targeted treatment.